InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pafah1b1

Summary

InnateDB Protein

IDBP-542606.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pafah1b1

Protein Name

platelet-activating factor acetylhydrolase, isoform 1b, subunit 1

Synonyms

LIS-1; Lis1; Mdsh; MMS10-U; Ms10u; Pafaha;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000118231

InnateDB Gene

IDBG-198862 (Pafah1b1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.

Experimentally validated
Total	33 [view]
Protein-Protein	32 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	31 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0042803	protein homodimerization activity
GO:0045505	dynein intermediate chain binding
GO:0051219	phosphoprotein binding

Biological Process

GO:0000132	establishment of mitotic spindle orientation
GO:0000226	microtubule cytoskeleton organization
GO:0001667	ameboidal cell migration
GO:0001675	acrosome assembly
GO:0001764	neuron migration
GO:0001961	positive regulation of cytokine-mediated signaling pathway
GO:0007097	nuclear migration
GO:0007268	synaptic transmission
GO:0007405	neuroblast proliferation
GO:0007611	learning or memory
GO:0008090	retrograde axon cargo transport
GO:0008344	adult locomotory behavior
GO:0009306	protein secretion
GO:0010977	negative regulation of neuron projection development
GO:0016477	cell migration
GO:0017145	stem cell division
GO:0019226	transmission of nerve impulse
GO:0021540	corpus callosum morphogenesis
GO:0021766	hippocampus development
GO:0021819	layer formation in cerebral cortex
GO:0021895	cerebral cortex neuron differentiation
GO:0021987	cerebral cortex development
GO:0030036	actin cytoskeleton organization
GO:0031023	microtubule organizing center organization
GO:0032319	regulation of Rho GTPase activity
GO:0036035	osteoclast development
GO:0045773	positive regulation of axon extension
GO:0045931	positive regulation of mitotic cell cycle
GO:0046329	negative regulation of JNK cascade
GO:0047496	vesicle transport along microtubule
GO:0048854	brain morphogenesis
GO:0050885	neuromuscular process controlling balance
GO:0051081	nuclear envelope disassembly
GO:0051660	establishment of centrosome localization

Cellular Component

GO:0000235	astral microtubule
GO:0000776	kinetochore
GO:0005635	nuclear envelope
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005829	cytosol
GO:0005871	kinesin complex
GO:0005875	microtubule associated complex
GO:0005938	cell cortex
GO:0015630	microtubule cytoskeleton
GO:0030426	growth cone
GO:0031252	cell leading edge
GO:0031512	motile primary cilium
GO:0031982	vesicle
GO:0043025	neuronal cell body
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

MGI:109520

InterPro

IPR006594 LisH dimerisation motif
IPR013720 LisH dimerisation motif, subgroup

PFAM

PF08513

PRINTS

PIRSF

SMART

SM00667

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

Q5SW16

UniProt Splice Variant

Entrez Gene

18472

UniGene

Mm.473922

RefSeq

MGI ID

MGI Symbol

Pafah1b1

OMIM

CCDS

HPRD

IMGT

EMBL

AK160764 AL607024

GenPept

BAE35996