InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Eif2ak3

Summary

InnateDB Protein

IDBP-542629.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Eif2ak3

Protein Name

eukaryotic translation initiation factor 2 alpha kinase 3

Synonyms

AI427929; Pek; Perk;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000123759

InnateDB Gene

IDBG-155036 (Eif2ak3)

Protein Structure

UniProt Annotation

Function

Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1). Involved in control of mitochondrial morphology and function. {ECO:0000269PubMed:11035797, ECO:0000269PubMed:23921556}.

Subcellular Localization

Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0001501	skeletal system development
GO:0001503	ossification
GO:0002063	chondrocyte development
GO:0006412	translation
GO:0006468	protein phosphorylation
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006983	ER overload response
GO:0007029	endoplasmic reticulum organization
GO:0007595	lactation
GO:0009967	positive regulation of signal transduction
GO:0010629	negative regulation of gene expression
GO:0017148	negative regulation of translation
GO:0019217	regulation of fatty acid metabolic process
GO:0019722	calcium-mediated signaling
GO:0030282	bone mineralization
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0031016	pancreas development
GO:0031018	endocrine pancreas development
GO:0031642	negative regulation of myelination
GO:0032092	positive regulation of protein binding
GO:0032933	SREBP signaling pathway
GO:0043066	negative regulation of apoptotic process
GO:0045444	fat cell differentiation
GO:0046777	protein autophosphorylation
GO:0048009	insulin-like growth factor receptor signaling pathway
GO:0051260	protein homooligomerization
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress