InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Kif26a

Summary

InnateDB Protein

IDBP-542728.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kif26a

Protein Name

kinesin family member 26A

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000119482

InnateDB Gene

IDBG-174227 (Kif26a)

Protein Structure

UniProt Annotation

Function

Atypical kinesin that plays a key role in enteric neuron development. Acts by repressing a cell growth signaling pathway in the enteric nervous system development, possibly via its interaction with GRB2 that prevents GRB2-binding to SHC, thereby attenating the GDNF-Ret signaling. Binds to microtubules but lacks microtubule-based motility due to the absence of ATPase activity. {ECO:0000269PubMed:19914172}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in several neuronal populations. {ECO:0000269PubMed:19914172}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003777	microtubule motor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008017	microtubule binding

Biological Process

GO:0001560	regulation of cell growth by extracellular stimulus
GO:0007018	microtubule-based movement
GO:0009968	negative regulation of signal transduction
GO:0048484	enteric nervous system development