InnateDB Protein
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IDBP-542745.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Unc93b1
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Protein Name
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unc-93 homolog B1 (C. elegans)
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Synonyms
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Unc-93B1; Unc93b;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000124272
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InnateDB Gene
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IDBG-128581 (Unc93b1)
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Protein Structure
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Function |
Plays an important role in innate and adaptive immunity by regulating nucleotide-sensing Toll-like receptor (TLR) signaling. Required for the transport of a subset of TLRs (including TLR3, TLR7 and TLR9) from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. May play a role in autoreactive B- cells removal. {ECO:0000269PubMed:16415873, ECO:0000269PubMed:17452530, ECO:0000269PubMed:18305481}.
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Subcellular Localization |
Endoplasmic reticulum membrane; Multi-pass membrane protein. Endosome. Lysosome. Cytoplasmic vesicle, phagosome. Note=Colocalizes with LAMP5 in large endosomal intracellular vesicles (By similarity). Relocalizes from endoplasmic reticulum to endosome and lysosome upon cell- stimulation with CpG dinucleotides. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.
Experimentally validated |
Total |
14
[view]
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Protein-Protein |
14
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
29 [view]
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Molecular Function |
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Biological Process |
GO:0002224
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toll-like receptor signaling pathway
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GO:0006886
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intracellular protein transport
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GO:0019886
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antigen processing and presentation of exogenous peptide antigen via MHC class II
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GO:0034138
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toll-like receptor 3 signaling pathway
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GO:0034154
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toll-like receptor 7 signaling pathway
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GO:0034162
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toll-like receptor 9 signaling pathway
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GO:0045087
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innate immune response (InnateDB)
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GO:0051607
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defense response to virus
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Cellular Component |
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PDB ID |
MGI:1859307
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InterPro |
IPR010291
Ion channel regulatory protein, UNC-93
IPR016196
Major facilitator superfamily domain, general substrate transporter
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PFAM |
PF05978
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8VCW4
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PhosphoSite |
PhosphoSite-Q8VCW4
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TrEMBL |
E9PYK0
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UniProt Splice Variant |
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Entrez Gene |
54445
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UniGene |
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RefSeq |
NP_062322
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MGI ID |
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MGI Symbol |
Unc93b1
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OMIM |
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CCDS |
CCDS29404
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HPRD |
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IMGT |
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EMBL |
AC133523
AJ422144
AK165060
BC018388
BC023731
BC025587
U89424
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GenPept |
AAC36530
AAH18388
AAH23731
AAH25587
BAE38019
CAD19524
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