InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Khdrbs1

Summary

InnateDB Protein

IDBP-542958.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Khdrbs1

Protein Name

KH domain containing, RNA binding, signal transduction associated 1

Synonyms

p62; p68; Sam68;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000115402

InnateDB Gene

IDBG-191571 (Khdrbs1)

Protein Structure

UniProt Annotation

Function

Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain- containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. Positively regulates the association of constitutive transport element (CTE)-containing mRNA with large polyribosomes and translation initiation. May not be involved in the nucleocytoplasmic export of unspliced (CTE)- containing RNA species. {ECO:0000269PubMed:12496368, ECO:0000269PubMed:7512695, ECO:0000269PubMed:9315629}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:12496368}. Membrane {ECO:0000269PubMed:12496368}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 130 interaction(s) predicted by orthology.

Experimentally validated
Total	35 [view]
Protein-Protein	33 [view]
Protein-DNA	0
Protein-RNA	2 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	130 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0005070	SH3/SH2 adaptor activity
GO:0005515	protein binding
GO:0008143	poly(A) binding
GO:0008266	poly(U) RNA binding
GO:0017124	SH3 domain binding
GO:0032403	protein complex binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0007049	cell cycle
GO:0007166	cell surface receptor signaling pathway
GO:0009967	positive regulation of signal transduction
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045948	positive regulation of translational initiation
GO:0046831	regulation of RNA export from nucleus
GO:0046833	positive regulation of RNA export from nucleus