InnateDB Protein
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IDBP-54316.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SPRED2
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Protein Name
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sprouty-related, EVH1 domain containing 2
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000348753
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InnateDB Gene
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IDBG-54314 (SPRED2)
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Protein Structure
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Function |
Tyrosine kinase substrate that inhibits growth-factor- mediated activation of MAP kinase.
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Subcellular Localization |
Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasm. Note=Especially found in the cytoplasm of the stratum spinosum cells called membrane-coated granules.
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Disease Associations |
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Tissue Specificity |
Expressed in liver, skin, small intestine, salivary gland and prostate. {ECO:0000269PubMed:15580519}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
7
[view]
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Protein-Protein |
6
[view]
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Protein-DNA |
0
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
GO:0000188
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inactivation of MAPK activity
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GO:0007275
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multicellular organismal development
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GO:0009966
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regulation of signal transduction
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GO:0010801
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negative regulation of peptidyl-threonine phosphorylation
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GO:0043517
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positive regulation of DNA damage response, signal transduction by p53 class mediator
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GO:0090311
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regulation of protein deacetylation
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Cellular Component |
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PDB ID |
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InterPro |
IPR000697
WH1/EVH1
IPR007875
Sprouty
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PFAM |
PF00568
PF05210
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PRINTS |
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PIRSF |
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SMART |
SM00461
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TIGRFAMs |
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Modification |
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SwissProt |
Q7Z698
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PhosphoSite |
PhosphoSite-Q7Z698
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TrEMBL |
C9J623
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UniProt Splice Variant |
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Entrez Gene |
200734
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UniGene |
Hs.59332
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RefSeq |
NP_861449
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HUGO |
HGNC:17722
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OMIM |
609292
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CCDS |
CCDS33211
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HPRD |
18100
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IMGT |
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EMBL |
AC012370
AC097503
AK299079
AY299090
BC111495
BC130292
BC136334
CH471053
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GenPept |
AAI11496
AAI30293
AAI36335
AAP59415
BAH12943
EAW99905
EAW99906
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