Version 5.4
Homo sapiens Protein: CHAMP1
Summary
InnateDB Protein IDBP-54427.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CHAMP1
Protein Name chromosome alignment maintaining phosphoprotein 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000354730
InnateDB Gene IDBG-54423 (CHAMP1)
Protein Structure
UniProt Annotation
Function Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269PubMed:21063390}.
Subcellular Localization Nucleus {ECO:0000269PubMed:21063390}. Chromosome {ECO:0000269PubMed:21063390}. Chromosome, centromere, kinetochore {ECO:0000269PubMed:21063390}. Cytoplasm, cytoskeleton, spindle {ECO:0000269PubMed:21063390}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0031134 sister chromatid biorientation
GO:0034501 protein localization to kinetochore
GO:0035372 protein localization to microtubule
GO:0051315 attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation
Cellular Component
GO:0000777 condensed chromosome kinetochore
GO:0000793 condensed chromosome
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005819 spindle
Protein Structure and Domains
PDB ID
InterPro IPR007087 Zinc finger, C2H2
IPR015880 Zinc finger, C2H2-like
PFAM PF00096
PRINTS
PIRSF
SMART SM00355
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96JM3
PhosphoSite PhosphoSite-Q96JM3
TrEMBL S4R3K0
UniProt Splice Variant
Entrez Gene 283489
UniGene Hs.7542
RefSeq NP_115812
HUGO HGNC:20311
OMIM
CCDS CCDS9545
HPRD 10707
IMGT
EMBL AB058705 AK074894 AK096346 AL160396 AL845154 BC004820 BC065237 CH471085
GenPept AAH04820 AAH65237 BAB47431 BAC11273 BAG53268 CAI23600 EAX09253

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca