InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FAT2

Summary

InnateDB Protein

IDBP-54526.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FAT2

Protein Name

FAT tumor suppressor homolog 2 (Drosophila)

Synonyms

CDHF8; CDHR9; HFAT2; MEGF1;

Species

Homo sapiens

Ensembl Protein

ENSP00000261800

InnateDB Gene

IDBG-54524 (FAT2)

Protein Structure

UniProt Annotation

Function

Plays a role in the migration of epidermal cells. May modulate the extracellular space surronding parallel fibers of cerebellar during development (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell junction {ECO:0000269PubMed:17900869}. Nucleus {ECO:0000269PubMed:17900869}. Note=Localized at adhesion zippers (early state of adherens junctions) of keratinocytes.

Disease Associations

Tissue Specificity

Expressed in epidermal keratinocytes, infant brain, cerebellum, and also in a variety of tumors, such as pancreatic cancer, diffuse type gastric cancer, ovarian cancer, esophageal cancer, skin squamous cell carcinoma, head and neck cancer. Not expressed in melanoma cell line A375 cells, normal epidermal melanocytes or normal dermal fibroblasts. Expressed in epidermal keratinocytes and squamous cell carcinoma (at protein level). {ECO:0000269PubMed:16865240, ECO:0000269PubMed:17900869}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0007156	homophilic cell adhesion
GO:0010631	epithelial cell migration

Cellular Component

GO:0005634	nucleus
GO:0005886	plasma membrane
GO:0005913	cell-cell adherens junction
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000742 Epidermal growth factor-like domain
IPR001791 Laminin G domain
IPR001881 EGF-like calcium-binding domain
IPR002126 Cadherin
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR015919 Cadherin-like

PFAM

PF00008
PF00054
PF02210
PF07645
PF00028

PRINTS

PR00205

PIRSF

SMART

SM00181
SM00210
SM00282
SM00179
SM00112

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt