InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PROKR1

Summary

InnateDB Protein

IDBP-54629.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PROKR1

Protein Name

prokineticin receptor 1

Synonyms

GPR73; GPR73a; PKR1; ZAQ;

Species

Homo sapiens

Ensembl Protein

ENSP00000303775

InnateDB Gene

IDBG-54627 (PROKR1)

Protein Structure

UniProt Annotation

Function

Receptor for prokineticin 1. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase. May play a role during early pregnancy. {ECO:0000269PubMed:18339712}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Localizes to glandular epithelium, stroma and vascular endothelial cells of first trimester decidua (at protein level). Up-regulated in first trimester decidua when compared with non-pregnant endometrium. Expressed in the stomach, throughout the small intestine, colon, rectum, thyroid gland, pituitary gland, salivary gland, adrenal gland, testis, ovary, brain, spleen, prostate and pancreas. {ECO:0000269PubMed:18339712}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004983	neuropeptide Y receptor activity

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007218	neuropeptide signaling pathway
GO:0043066	negative regulation of apoptotic process

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000611 Neuropeptide Y receptor family
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00237
PR01012

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8TCW9