InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: APPL2

Summary

InnateDB Protein

IDBP-54654.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

APPL2

Protein Name

adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000258530

InnateDB Gene

IDBG-54652 (APPL2)

Protein Structure

UniProt Annotation

Function

Required for the regulation of cell proliferation in response to extracellular signals mediated by an early endosomal compartment. Links Rab5 to nuclear signal transduction. {ECO:0000269PubMed:15016378}.

Subcellular Localization

Early endosome membrane {ECO:0000269PubMed:15016378}; Peripheral membrane protein {ECO:0000269PubMed:15016378}. Nucleus {ECO:0000269PubMed:15016378}. Note=Early endosomal membrane-bound and nuclear. Translocated into the nucleus upon release from endosomal membranes following internalization of EGF.

Disease Associations

Note=A chromosomal aberration involving APPL2/DIP13B is found in patients with chromosome 22q13.3 deletion syndrome. Translocation t(12;22)(q24.1;q13.3) with SHANK3/PSAP2.

Tissue Specificity

High levels in brain, heart, kidney and skeletal muscle. {ECO:0000269PubMed:11431708}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0007049	cell cycle
GO:0007165	signal transduction
GO:0008283	cell proliferation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0010008	endosome membrane
GO:0016581	NuRD complex
GO:0031901	early endosome membrane
GO:0070062	extracellular vesicular exosome