InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CHST13

Summary

InnateDB Protein

IDBP-54676.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHST13

Protein Name

carbohydrate (chondroitin 4) sulfotransferase 13

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000317404

InnateDB Gene

IDBG-54674 (CHST13)

Protein Structure

UniProt Annotation

Function

Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Transfers sulfate to the C4 hydroxyl of beta1,4-linked GalNAc that is substituted with a beta-linked glucuronic acid at the C-3 hydroxyl. No activity toward dermatan.

Subcellular Localization

Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in adult liver. Expressed at lower level in kidney, lymph nodes and fetal kidney. {ECO:0000269PubMed:12080076}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001537	N-acetylgalactosamine 4-O-sulfotransferase activity
GO:0008146	sulfotransferase activity
GO:0047756	chondroitin 4-sulfotransferase activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0016051	carbohydrate biosynthetic process
GO:0030203	glycosaminoglycan metabolic process
GO:0030204	chondroitin sulfate metabolic process
GO:0030206	chondroitin sulfate biosynthetic process
GO:0044281	small molecule metabolic process