Version 5.4
Homo sapiens Protein: GKN1
Summary
InnateDB Protein IDBP-54696.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GKN1
Protein Name gastrokine 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000367172
InnateDB Gene IDBG-54694 (GKN1)
Protein Structure
UniProt Annotation
Function Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium. {ECO:0000269PubMed:12851218}.
Subcellular Localization Secreted {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in stomach. No expression is detected in cancer tissue or gastric cancer cell lines. {ECO:0000269PubMed:10835488, ECO:0000269PubMed:12851218}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0008083 growth factor activity
Biological Process
GO:0007586 digestion
GO:0008284 positive regulation of cell proliferation
GO:0051781 positive regulation of cell division
Cellular Component
GO:0005575 cellular_component
GO:0005576 extracellular region
GO:0030141 secretory granule
Protein Structure and Domains
PDB ID
InterPro IPR007084 BRICHOS domain
PFAM PF04089
PRINTS
PIRSF
SMART SM01039
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NS71
PhosphoSite PhosphoSite-Q9NS71
TrEMBL Q53YU7
UniProt Splice Variant
Entrez Gene 56287
UniGene
RefSeq NP_062563
HUGO HGNC:23217
OMIM 606402
CCDS CCDS1891
HPRD 16217
IMGT
EMBL AB039886 AC114802 AJ966789 AY139182 AY139184 AY359050 AY456961 BC059778
GenPept AAH59778 AAN75447 AAN75449 AAQ89409 AAR21211 AAY24066 BAA92433 CAI85015

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca