InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KRTAP10-10

Summary

InnateDB Protein

IDBP-5476.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KRTAP10-10

Protein Name

keratin associated protein 10-10

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000369438

InnateDB Gene

IDBG-281545 (KRTAP10-10)

Protein Structure

UniProt Annotation

Function

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins.

Subcellular Localization

Disease Associations

Tissue Specificity

Restricted to a narrow region of the hair fiber cuticle, lying approximately 20 cell layers above the apex of the dermal papilla of the hair root; not detected in any other tissues. {ECO:0000269PubMed:14962103, ECO:0000269PubMed:15028290}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

Cellular Component

GO:0045095

keratin filament