Homo sapiens Protein: GALNT10
Summary
InnateDB Protein IDBP-54811.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GALNT10
Protein Name UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000366889
InnateDB Gene IDBG-54807 (GALNT10)
Protein Structure
UniProt Annotation
Function Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward Muc5Ac and EA2 peptide substrates.
Subcellular Localization Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Widely expressed. Expressed at high level in small intestine, and at intermediate levels in stomach, pancreas, ovary, thyroid gland and spleen. Weakly expressed in other tissues. {ECO:0000269PubMed:12417297}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0016266 O-glycan processing
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0000139 Golgi membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000772 Ricin B lectin domain
IPR001173 Glycosyltransferase 2-like
IPR029044 Nucleotide-diphospho-sugar transferases
PFAM PF00652
PF14200
PF00535
PRINTS
PIRSF
SMART SM00458
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q86SR1
PhosphoSite PhosphoSite-Q86SR1
TrEMBL Q4G0E1
UniProt Splice Variant
Entrez Gene 55568
UniGene Hs.740431
RefSeq
HUGO HGNC:19873
OMIM 608043
CCDS
HPRD 12157
IMGT
EMBL AB078145 AJ505950 AK023782 AK074132 AK127135 AL096739 BC007224 BC072450 BC098444
GenPept AAH07224 AAH72450 AAH98444 BAB14676 BAB84958 BAC56890 BAG54441 CAB46378 CAD44532