Version 5.4
Homo sapiens Protein: GMCL1
Summary
InnateDB Protein IDBP-55008.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GMCL1
Protein Name germ cell-less homolog 1 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000282570
InnateDB Gene IDBG-55006 (GMCL1)
Protein Structure
UniProt Annotation
Function Possible function in spermatogenesis. Enhances the degradation of MDM2 and increases the amount of p53 probably by modulating the nucleocytoplasmic transport (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus matrix {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0007275 multicellular organismal development
GO:0007283 spermatogenesis
GO:0030154 cell differentiation
Cellular Component
GO:0005635 nuclear envelope
GO:0016363 nuclear matrix
Protein Structure and Domains
PDB ID
InterPro IPR000210 BTB/POZ-like
IPR011333 BTB/POZ fold
IPR011705 BTB/Kelch-associated
IPR013069 BTB/POZ
PFAM PF07707
PF00651
PRINTS
PIRSF
SMART SM00225
SM00875
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96IK5
PhosphoSite PhosphoSite-Q96IK5
TrEMBL Q53SE7
UniProt Splice Variant
Entrez Gene 64395
UniGene Hs.729670
RefSeq NP_848526
HUGO HGNC:23843
OMIM
CCDS CCDS1895
HPRD 13587
IMGT
EMBL AC019206 AK023119 AK023261 AK024042 BC007420 CH471053
GenPept AAH07420 AAY14865 BAB14416 BAB14494 BAB14796 EAW99842

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca