InnateDB Protein
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IDBP-55077.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MXD1
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Protein Name
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MAX dimerization protein 1
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Synonyms
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BHLHC58; MAD; MAD1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000264444
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InnateDB Gene
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IDBG-55075 (MXD1)
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Protein Structure
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Function |
Transcriptional repressor. MAD binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MAD thus antagonizes MYC transcriptional activity by competing for MAX.
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Subcellular Localization |
Nucleus.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated |
Total |
33
[view]
|
Protein-Protein |
27
[view]
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Protein-DNA |
5
[view]
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Protein-RNA |
0
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DNA-DNA |
1
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
5 [view]
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|
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Molecular Function |
Accession |
GO Term |
GO:0000978
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RNA polymerase II core promoter proximal region sequence-specific DNA binding
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GO:0001078
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RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
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GO:0003700
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sequence-specific DNA binding transcription factor activity
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GO:0003712
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transcription cofactor activity
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GO:0003714
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transcription corepressor activity
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GO:0046983
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protein dimerization activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR011598
Myc-type, basic helix-loop-helix (bHLH) domain
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PFAM |
PF00010
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PRINTS |
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PIRSF |
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SMART |
SM00353
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TIGRFAMs |
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Modification |
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SwissProt |
Q05195
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PhosphoSite |
PhosphoSite-Q05195
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TrEMBL |
C9JBE8
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UniProt Splice Variant |
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Entrez Gene |
4084
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UniGene |
Hs.707656
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RefSeq |
NP_002348
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HUGO |
HGNC:6761
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OMIM |
600021
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CCDS |
CCDS1896
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HPRD |
02487
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IMGT |
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EMBL |
AC019206
AK312734
BC069377
BC069433
BC098396
BC113531
BC117260
BC143831
BC143832
CH471053
CR536495
CR541692
L06895
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GenPept |
AAA36194
AAH69377
AAH69433
AAH98396
AAI13532
AAI17261
AAI43832
AAI43833
AAY14867
BAG35605
CAG38734
CAG46493
EAW99839
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