InnateDB Protein
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IDBP-55090.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MACROD2
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Protein Name
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MACRO domain containing 2
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000217246
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InnateDB Gene
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IDBG-55088 (MACROD2)
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Protein Structure
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Function |
Removes ADP-ribose from glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. {ECO:0000269PubMed:21257746, ECO:0000269PubMed:23474712}.
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Subcellular Localization |
Nucleus. Note=Recruited to DNA lesions, probably via mono-APD-ribosylated proteins.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0016798
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hydrolase activity, acting on glycosyl bonds
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GO:0019213
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deacetylase activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002589
Macro domain
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PFAM |
PF01661
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PRINTS |
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PIRSF |
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SMART |
SM00506
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TIGRFAMs |
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Modification |
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SwissProt |
A1Z1Q3
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PhosphoSite |
PhosphoSite-A1Z1Q3
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
140733
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UniGene |
Hs.661576
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RefSeq |
NP_542407
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HUGO |
HGNC:16126
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OMIM |
611567
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CCDS |
CCDS13120
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HPRD |
16640
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IMGT |
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EMBL |
AC006198
AK125899
AK131348
AL035073
AL049633
AL049867
AL050324
AL079338
AL117333
AL118503
AL118510
AL121582
AL121584
AL132826
AL133462
AL136991
AL136992
AL138808
AL139825
AL158088
AL161800
AL353798
AL354773
AL355133
AL357654
BC018687
BC035876
BC101216
BC101217
BC101218
BC101219
BC126936
CH471133
EF159161
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GenPept |
AAH18687
ABM46908
BAD18504
BAG54262
CAH71976
CAI16368
CAM14046
CAM18337
CAM26942
CAM27056
CAM27329
CAM28281
CAM28328
CAM28330
CAQ06880
CAQ06881
CAQ07295
CAQ08720
CAQ08721
EAX10293
EAX10302
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