InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ASPRV1

Summary

InnateDB Protein

IDBP-55113.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ASPRV1

Protein Name

aspartic peptidase, retroviral-like 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000315383

InnateDB Gene

IDBG-406519 (ASPRV1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.

Disease Associations

Tissue Specificity

Expressed primarily in the granular layer of the epidermis and inner root sheath of hair follicles. In psoriatic skin, expressed throughout the stratum corneum. In ulcerated skin, expressed in the stratum granulosum of intact epidermis but almost absent from ulcerated regions. Expressed in differentiated areas of squamous cell carcinomas but not in undifferentiated tumors. {ECO:0000269PubMed:16098038, ECO:0000269PubMed:16565508}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004190	aspartic-type endopeptidase activity

Biological Process

GO:0006508	proteolysis
GO:0016485	protein processing
GO:0043588	skin development

Cellular Component

GO:0016021

integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001995 Peptidase A2A, retrovirus, catalytic
IPR018061 Peptidase A2A, retrovirus RVP subgroup
IPR019103 Aspartic peptidase, DDI1-type
IPR021109 Aspartic peptidase domain

PFAM

PF00077
PF09668

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q53RT3

PhosphoSite