Version 5.4
Homo sapiens Protein: PCBP1
Summary
InnateDB Protein IDBP-55133.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PCBP1
Protein Name poly(rC) binding protein 1
Synonyms HEL-S-85; hnRNP-E1; hnRNP-X; HNRPE1; HNRPX;
Species Homo sapiens
Ensembl Protein ENSP00000305556
InnateDB Gene IDBG-55131 (PCBP1)
Protein Structure
UniProt Annotation
Function Single-stranded nucleic acid binding protein that binds preferentially to oligo dC.
Subcellular Localization Nucleus. Cytoplasm. Note=Loosely bound in the nucleus. May shuttle between the nucleus and the cytoplasm.
Disease Associations
Tissue Specificity Abundantly expressed in skeletal muscle, thymus and peripheral blood leukocytes while a lower expression is observed in prostate, spleen, testis, ovary, small intestine, heart, liver, adrenal and thyroid glands.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 119 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 119 [view]
Protein-Protein 116 [view]
Protein-DNA 2 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003697 single-stranded DNA binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0008380 RNA splicing
GO:0010467 gene expression
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0030529 ribonucleoprotein complex
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR004044 K Homology domain, type 2
IPR004087 K Homology domain
IPR004088 K Homology domain, type 1
PFAM PF07650
PF00013
PF13014
PRINTS
PIRSF
SMART SM00322
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q15365
PhosphoSite PhosphoSite-Q15365
TrEMBL Q53SS8
UniProt Splice Variant
Entrez Gene 5093
UniGene Hs.613714
RefSeq NP_006187
HUGO HGNC:8647
OMIM 601209
CCDS CCDS1898
HPRD 03128
IMGT
EMBL AC016700 AK314225 BC039742 CH471053 FJ224329 U24223 X78137 Z29505
GenPept AAA91317 AAH39742 AAX93191 ACI46021 BAG36897 CAA55016 CAA82631 EAW99834

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca