Version 5.4
| Homo sapiens Protein: SPPL2C | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-55139.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | SPPL2C | ||||||||
| Protein Name | Signal peptide peptidase-like 2C | ||||||||
| Synonyms | |||||||||
| Species | Homo sapiens | ||||||||
| Ensembl Protein | ENSP00000332488 | ||||||||
| InnateDB Gene | IDBG-55137 (SPPL2C) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Intramembrane-cleaving aspartic protease (I-CLiP) that may be able to cleave type II membrane signal peptides in the hydrophobic plane of the membrane. {ECO:0000250}. | ||||||||
| Subcellular Localization | Membrane {ECO:0000305PubMed:16829952}; Multi-pass membrane protein {ECO:0000305PubMed:16829952}. Endoplasmic reticulum membrane {ECO:0000269PubMed:16829952}; Multi-pass membrane protein {ECO:0000269PubMed:16829952}. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | Ubiquitous. {ECO:0000269PubMed:15385547}. | ||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | |||||||||
| InterPro |
IPR003137
Protease-associated domain, PA IPR006639 Presenilin/signal peptide peptidase IPR007369 Peptidase A22B, signal peptide peptidase |
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| PFAM |
PF02225
PF04258 |
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| PRINTS | |||||||||
| PIRSF | |||||||||
| SMART |
SM00730
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| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | Q8IUH8 | ||||||||
| PhosphoSite | PhosphoSite-Q8IUH8 | ||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 162540 | ||||||||
| UniGene | Hs.144491 | ||||||||
| RefSeq | NP_787078 | ||||||||
| HUGO | HGNC:28902 | ||||||||
| OMIM | 608284 | ||||||||
| CCDS | CCDS32673 | ||||||||
| HPRD | 07085 | ||||||||
| IMGT | |||||||||
| EMBL | AC003662 AC217770 AC217771 AY169316 BC022041 BC025401 | ||||||||
| GenPept | AAH22041 AAH25401 AAO12541 | ||||||||