InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UBE2G2

Summary

InnateDB Protein

IDBP-5514.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UBE2G2

Protein Name

ubiquitin-conjugating enzyme E2G 2

Synonyms

UBC7;

Species

Homo sapiens

Ensembl Protein

ENSP00000338348

InnateDB Gene

IDBG-5510 (UBE2G2)

Protein Structure

UniProt Annotation

Function

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 48'-linked polyubiquitination. Involved in endoplasmic reticulum- associated degradation (ERAD). {ECO:0000269PubMed:20061386, ECO:0000269PubMed:22607976}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	54 [view]
Protein-Protein	51 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016881	acid-amino acid ligase activity

Biological Process

GO:0006511	ubiquitin-dependent protein catabolic process
GO:0018279	protein N-linked glycosylation via asparagine
GO:0030433	ER-associated ubiquitin-dependent protein catabolic process
GO:0070936	protein K48-linked ubiquitination