Version 5.4
Homo sapiens Protein: LYPD3
Summary
InnateDB Protein IDBP-55157.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LYPD3
Protein Name LY6/PLAUR domain containing 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000244333
InnateDB Gene IDBG-55155 (LYPD3)
Protein Structure
UniProt Annotation
Function Supports cell migration. May be involved in urothelial cell-matrix interactions. May be involved in tumor progression. {ECO:0000269PubMed:11179665, ECO:0000269PubMed:11245483, ECO:0000269PubMed:12592373, ECO:0000269PubMed:15012588}.
Subcellular Localization Cell membrane; Lipid-anchor, GPI-anchor.
Disease Associations
Tissue Specificity Expressed in placenta, skin and urothelium. Found in suprabasal keratinocytes of chronic wounds. Weak expression is found in esophagus and peripheral blood mononuclear cells. Found in the majority of primary and metastatic transitional cell carcinomas (TCCs) and as well in breast cancer tissues, but not in adjacent normal tissues. High expression is found in the tumor component of some noninvasive superficial lesions and in invasive and metastatic urothelial cancers. {ECO:0000269PubMed:11179665, ECO:0000269PubMed:12592373, ECO:0000269PubMed:15012588}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0043236 laminin binding
Biological Process
GO:0006928 cellular component movement
GO:0007160 cell-matrix adhesion
Cellular Component
GO:0005615 extracellular space
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0046658 anchored component of plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR001526 CD59 antigen
IPR016054 Ly-6 antigen / uPA receptor -like
PFAM PF00021
PRINTS
PIRSF
SMART SM00134
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O95274
PhosphoSite PhosphoSite-O95274
TrEMBL B2RBR3
UniProt Splice Variant
Entrez Gene 27076
UniGene
RefSeq NP_055215
HUGO HGNC:24880
OMIM 609484
CCDS CCDS12620
HPRD 10783
IMGT
EMBL AC018758 AF082889 AJ223603 AK075464 AK314773 AY359006 BC039167 CH471126
GenPept AAD13751 AAG09062 AAH39167 AAQ89365 BAG37310 BAG52146 CAA11469 EAW57190

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca