Version 5.4
Homo sapiens Protein: DNAJB8
Summary
InnateDB Protein IDBP-55190.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DNAJB8
Protein Name DnaJ (Hsp40) homolog, subfamily B, member 8
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000316053
InnateDB Gene IDBG-55188 (DNAJB8)
Protein Structure
UniProt Annotation
Function Efficient suppressor of aggregation and toxicity of disease-associated polyglutamine proteins. {ECO:0000269PubMed:20159555}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0044183 protein binding involved in protein folding
GO:0051082 unfolded protein binding
GO:0051087 chaperone binding
Biological Process
GO:0061077 chaperone-mediated protein folding
GO:0090084 negative regulation of inclusion body assembly
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR001623 DnaJ domain
PFAM PF00226
PRINTS PR00625
PIRSF
SMART SM00271
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8NHS0
PhosphoSite PhosphoSite-Q8NHS0
TrEMBL
UniProt Splice Variant
Entrez Gene 165721
UniGene Hs.743112
RefSeq NP_699161
HUGO HGNC:23699
OMIM 611337
CCDS CCDS3048
HPRD 09921
IMGT
EMBL AK125946 AK126068 BC029521 BC050288 CH471052
GenPept AAH29521 AAH50288 BAG54269 BAG54285 EAW79320

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca