InnateDB Protein
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IDBP-55308.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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KIF16B
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Protein Name
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kinesin family member 16B
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000347995
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InnateDB Gene
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IDBG-55302 (KIF16B)
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Protein Structure
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Function |
Plus end-directed microtubule-dependent motor protein involved in endosome transport and receptor recycling and degradation. Regulates the plus end motility of early endosomes and the balance between recycling and degradation of receptors such as EGF receptor (EGFR) and FGF receptor (FGFR). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. {ECO:0000269PubMed:15882625}.
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Subcellular Localization |
Cytoplasm, cytoskeleton {ECO:0000305}. Early endosome membrane. Note=It is unclear whether association with endosomes is mediated via phosphatidylinositol 3-phosphate (PtdIns(3)P)-binding or via its interaction with RAB14.
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Disease Associations |
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Tissue Specificity |
Primarily expressed in brain. Also present in kidney, liver, intestine, placenta, leukocytes, heart and skeletal muscle (at protein level). {ECO:0000269PubMed:15882625}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
4
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001683
Phox homologous domain
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PFAM |
PF00787
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PRINTS |
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PIRSF |
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SMART |
SM00312
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TIGRFAMs |
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Modification |
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SwissProt |
Q96L93
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PhosphoSite |
PhosphoSite-Q96L93
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
55614
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UniGene |
Hs.595872
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RefSeq |
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HUGO |
HGNC:15869
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OMIM |
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CCDS |
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HPRD |
10731
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IMGT |
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EMBL |
AB046810
AK000142
AK026698
AK095322
AL049794
AL117376
AL118509
AY044654
AY166853
BC034984
BC110317
BC150261
BX647572
BX648426
CH471133
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GenPept |
AAH34984
AAI10318
AAI50262
AAK98768
AAO17292
BAA90971
BAB13416
BAB15530
CAI22745
CAI43062
CAI43063
CAI43179
CAI43180
CAI43181
CAI46105
CAI46266
CAM28305
CAM28307
EAX10290
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