InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CADM4

Summary

InnateDB Protein

IDBP-55401.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CADM4

Protein Name

cell adhesion molecule 4

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000222374

InnateDB Gene

IDBG-55399 (CADM4)

Protein Structure

UniProt Annotation

Function

Involved in the cell-cell adhesion. Has calcium- and magnesium-independent cell-cell adhesion activity. May have tumor- suppressor activity. {ECO:0000269PubMed:16261159}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in brain, prostate, brain, kidney and some other organs. {ECO:0000269PubMed:11536053, ECO:0000269PubMed:16261159}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0007155

cell adhesion

Cellular Component

GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR003585 Neurexin/syndecan/glycophorin C
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin
IPR013162 CD80-like, immunoglobulin C2-set

PFAM

PF07679
PF07686
PF00047
PF08205

PRINTS

PIRSF

SMART

SM00294
SM00408
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8NFZ8