InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SMG9

Summary

InnateDB Protein

IDBP-55554.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SMG9

Protein Name

smg-9 homolog, nonsense mediated mRNA decay factor (C. elegans)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000270066

InnateDB Gene

IDBG-55552 (SMG9)

Protein Structure

UniProt Annotation

Function

Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG8 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required for the efficient association between SMG1 and SMG8. {ECO:0000269PubMed:19417104}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	12 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042802	identical protein binding

Biological Process

GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0010467	gene expression
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process