InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ACO1

Summary

InnateDB Protein

IDBP-55577.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACO1

Protein Name

aconitase 1, soluble

Synonyms

ACONS; HEL60; IREB1; IREBP; IREBP1; IRP1;

Species

Homo sapiens

Ensembl Protein

ENSP00000369255

InnateDB Gene

IDBG-55575 (ACO1)

Protein Structure

UniProt Annotation

Function

Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding. {ECO:0000269PubMed:1946430, ECO:0000269PubMed:8041788}.Catalyzes the isomerization of citrate to isocitrate via cis-aconitate. {ECO:0000250}.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	12 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0003994	aconitate hydratase activity
GO:0005515	protein binding
GO:0030350	iron-responsive element binding
GO:0046872	metal ion binding
GO:0051539	4 iron, 4 sulfur cluster binding

Biological Process

GO:0006099	tricarboxylic acid cycle
GO:0006101	citrate metabolic process
GO:0008152	metabolic process
GO:0010040	response to iron(II) ion

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000573 Aconitase A/isopropylmalate dehydratase small subunit, swivel
IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha
IPR006249 Aconitate/iron regulatory protein 2
IPR015928 Aconitase/3-isopropylmalate dehydratase, swivel

PFAM

PF00694
PF00330

PRINTS

PR00415

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P21399