InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CDC42BPG

Summary

InnateDB Protein

IDBP-55618.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDC42BPG

Protein Name

CDC42 binding protein kinase gamma (DMPK-like)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000345133

InnateDB Gene

IDBG-55614 (CDC42BPG)

Protein Structure

UniProt Annotation

Function

May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation (By similarity). {ECO:0000250UniProtKB:Q5VT25}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:15194684}. Note=Concentrates at the leading edge of cells.

Disease Associations

Tissue Specificity

Expressed in heart and skeletal muscle. {ECO:0000269PubMed:15194684}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005083	small GTPase regulator activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0031532	actin cytoskeleton reorganization
GO:0035556	intracellular signal transduction
GO:0050790	regulation of catalytic activity

Cellular Component

GO:0005737	cytoplasm
GO:0031252	cell leading edge

Protein Structure and Domains

PDB ID

InterPro

IPR000095 CRIB domain
IPR000719 Protein kinase domain
IPR000961 AGC-kinase, C-terminal
IPR001180 Citron-like
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001849 Pleckstrin homology domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR014930 Myotonic dystrophy protein kinase, coiled coil
IPR017892 Protein kinase, C-terminal
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM