InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FIGLA

Summary

InnateDB Protein

IDBP-55621.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FIGLA

Protein Name

folliculogenesis specific basic helix-loop-helix

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000333097

InnateDB Gene

IDBG-55619 (FIGLA)

Protein Structure

UniProt Annotation

Function

Germline specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests that it may regulate additional pathways that are essential for normal ovarian development. Binds to the E- box (5'-CANNTG-3') of the ZPs (ZP1, ZP2, ZP3) promoters. {ECO:0000269PubMed:15044608}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Premature ovarian failure 6 (POF6) [MIM:612310]: An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol. {ECO:0000269PubMed:18499083}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Germ cells. Expressed in the fetal ovary, but not by a range of other tissues. Expression increases across mid- gestation, rising some 40-fold by the time of primordial follicle formation. {ECO:0000269PubMed:12468641, ECO:0000269PubMed:15044608}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008134	transcription factor binding
GO:0043565	sequence-specific DNA binding
GO:0046983	protein dimerization activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007275	multicellular organismal development
GO:0048599	oocyte development