InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: COPG

Summary

InnateDB Protein

IDBP-55632.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

COPG

Protein Name

coatomer protein complex, subunit gamma

Synonyms

COPG;

Species

Homo sapiens

Ensembl Protein

ENSP00000325002

InnateDB Gene

IDBG-55630 (COPG)

Protein Structure

UniProt Annotation

Function

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte triglyceride lipase (PNPLA2) with the lipid droplet surface to mediate lipolysis (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:11056392}. Golgi apparatus membrane {ECO:0000269PubMed:11056392}; Peripheral membrane protein {ECO:0000269PubMed:11056392}; Cytoplasmic side {ECO:0000269PubMed:11056392}. Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. Predominantly located in the cis-Golgi apparatus. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 70 experimentally validated interaction(s) in this database.

Experimentally validated
Total	70 [view]
Protein-Protein	70 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity
GO:0005488	binding
GO:0005515	protein binding

Biological Process

GO:0006886	intracellular protein transport
GO:0006890	retrograde vesicle-mediated transport, Golgi to ER
GO:0016192	vesicle-mediated transport
GO:0048205	COPI coating of Golgi vesicle
GO:0051683	establishment of Golgi localization
GO:0061024	membrane organization
GO:0072384	organelle transport along microtubule

Cellular Component

GO:0000139	Golgi membrane
GO:0005829	cytosol
GO:0030117	membrane coat
GO:0030126	COPI vesicle coat

Protein Structure and Domains

PDB ID

InterPro

IPR002553 Clathrin/coatomer adaptor, adaptin-like, N-terminal
IPR009028 Coatomer/calthrin adaptor appendage, C-terminal subdomain
IPR013040 Coatomer, gamma subunit, appendage, Ig-like subdomain
IPR013041 Coatomer/clathrin adaptor appendage, Ig-like subdomain
IPR016024 Armadillo-type fold
IPR017106 Coatomer gamma subunit

PFAM

PF01602
PF08752

PRINTS

PIRSF

PIRSF037093

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9Y678