Version 5.4
Homo sapiens Protein: MYOM2
Summary
InnateDB Protein IDBP-5564.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MYOM2
Protein Name myomesin (M-protein) 2, 165kDa
Synonyms TTNAP;
Species Homo sapiens
Ensembl Protein ENSP00000262113
InnateDB Gene IDBG-5562 (MYOM2)
Protein Structure
UniProt Annotation
Function Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent.
Subcellular Localization Cytoplasm, myofibril, sarcomere, M line {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008307 structural constituent of muscle
Biological Process
GO:0006936 muscle contraction
Cellular Component
GO:0005739 mitochondrion
GO:0031430 M band
GO:0032982 myosin filament
Protein Structure and Domains
PDB ID
InterPro IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR003961 Fibronectin, type III
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin
PFAM PF00041
PF01108
PF07679
PF07686
PF00047
PRINTS
PIRSF
SMART SM00408
SM00409
SM00060
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P54296
PhosphoSite PhosphoSite-P54296
TrEMBL
UniProt Splice Variant
Entrez Gene 9172
UniGene Hs.443683
RefSeq NP_003961
HUGO HGNC:7614
OMIM 603509
CCDS CCDS5957
HPRD 04619
IMGT
EMBL AC125453 BC052969 X69089
GenPept AAH52969 CAA48832

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca