Version 5.4
Homo sapiens Protein: THG1L
Summary
InnateDB Protein IDBP-55658.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol THG1L
Protein Name tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000231198
InnateDB Gene IDBG-55656 (THG1L)
Protein Structure
UniProt Annotation
Function Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis. {ECO:0000269PubMed:21059936}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:15459185}. Note=Found near the nuclear membrane.
Disease Associations
Tissue Specificity Expressed in many tissues. {ECO:0000269PubMed:15459185}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
Experimentally validated
Total 27 [view]
Protein-Protein 26 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000049 tRNA binding
GO:0000287 magnesium ion binding
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0008193 tRNA guanylyltransferase activity
GO:0042802 identical protein binding
Biological Process
GO:0006400 tRNA modification
GO:0008033 tRNA processing
GO:0051289 protein homotetramerization
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
Protein Structure and Domains
PDB ID
InterPro IPR007537 tRNAHis guanylyltransferase Thg1
IPR011335 Restriction endonuclease type II-like
IPR024956 tRNAHis guanylyltransferase catalytic domain
PFAM PF04446
PRINTS
PIRSF PIRSF028980
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NWX6
PhosphoSite PhosphoSite-Q9NWX6
TrEMBL Q9H8R6
UniProt Splice Variant
Entrez Gene 54974
UniGene Hs.734786
RefSeq NP_060342
HUGO HGNC:26053
OMIM
CCDS CCDS4341
HPRD 13726
IMGT
EMBL AK000553 AK021663 AK023355 AK223119 AL136669 AY463216 BC001523 BC001852 BC023521 CH471062 CR533503
GenPept AAH01523 AAH01852 AAH23521 AAS21134 BAA91249 BAB13870 BAB14540 BAD96839 CAB66604 CAG38534 EAW61590 EAW61591

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca