InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IRF4

Summary

InnateDB Protein

IDBP-55683.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IRF4

Protein Name

interferon regulatory factor 4

Synonyms

LSIRF; MUM1; NF-EM5;

Species

Homo sapiens

Ensembl Protein

ENSP00000370343

InnateDB Gene

IDBG-55681 (IRF4)

Protein Structure

UniProt Annotation

Function

Transcriptional activator. Binds to the interferon- stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus.

Disease Associations

Multiple myeloma (MM) [MIM:254500]: A malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. {ECO:0000269PubMed:9326949}. Note=The gene represented in this entry may be involved in disease pathogenesis. A chromosomal aberration involving IRF4 has been found in multiple myeloma. Translocation t(6;14)(p25;q32) with the IgH locus.

Tissue Specificity

Lymphoid cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 82 experimentally validated interaction(s) in this database.
They are also associated with 35 interaction(s) predicted by orthology.

Experimentally validated
Total	82 [view]
Protein-Protein	37 [view]
Protein-DNA	45 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	35 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000975	regulatory region DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0016279	protein-lysine N-methyltransferase activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006479	protein methylation
GO:0018022	peptidyl-lysine methylation
GO:0019221	cytokine-mediated signaling pathway
GO:0034122	negative regulation of toll-like receptor signaling pathway
GO:0042110	T cell activation
GO:0042832	defense response to protozoan
GO:0043011	myeloid dendritic cell differentiation
GO:0043388	positive regulation of DNA binding
GO:0043966	histone H3 acetylation
GO:0043967	histone H4 acetylation
GO:0045082	positive regulation of interleukin-10 biosynthetic process
GO:0045086	positive regulation of interleukin-2 biosynthetic process
GO:0045087	innate immune response (InnateDB)
GO:0045368	positive regulation of interleukin-13 biosynthetic process
GO:0045404	positive regulation of interleukin-4 biosynthetic process
GO:0045622	regulation of T-helper cell differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060333	interferon-gamma-mediated signaling pathway
GO:0060337	type I interferon signaling pathway
GO:0072540	T-helper 17 cell lineage commitment