InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LSM11

Summary

InnateDB Protein

IDBP-55715.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LSM11

Protein Name

LSM11, U7 small nuclear RNA associated

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000286307

InnateDB Gene

IDBG-55713 (LSM11)

Protein Structure

UniProt Annotation

Function

Component of the U7 snRNP complex that is involved in the histone 3'-end pre-mRNA processing (By similarity). Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed. Required for cell cycle progression from G1 to S phases. Binds specifically to the Sm-binding site of U7 snRNA. {ECO:0000250, ECO:0000269PubMed:16914750}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:12975319}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0071209	U7 snRNA binding

Biological Process

GO:0000084	mitotic S phase
GO:0006366	transcription from RNA polymerase II promoter
GO:0006369	termination of RNA polymerase II transcription
GO:0006398	histone mRNA 3'-end processing
GO:0008334	histone mRNA metabolic process
GO:0010467	gene expression
GO:0031124	mRNA 3'-end processing