InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ALKBH2

Summary

InnateDB Protein

IDBP-55759.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ALKBH2

Protein Name

alkB, alkylation repair homolog 2 (E. coli)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000343021

InnateDB Gene

IDBG-55757 (ALKBH2)

Protein Structure

UniProt Annotation

Function

Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1- ethenoadenine (in vitro). Has strong preference for double- stranded DNA. Has low efficiency with single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron. {ECO:0000269PubMed:12486230, ECO:0000269PubMed:12594517, ECO:0000269PubMed:16174769, ECO:0000269PubMed:18432238, ECO:0000269PubMed:18519673}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:12486230, ECO:0000269PubMed:12594517}. Note=Detected in replication foci during S-phase.

Disease Associations

Tissue Specificity

Detected in colon, small intestine, ovary, testis, prostate, skeletal muscle, heart, liver and urinary bladder. {ECO:0000269PubMed:12486230, ECO:0000269PubMed:16174769}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008198	ferrous iron binding
GO:0016491	oxidoreductase activity
GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0043734	DNA-N1-methyladenine dioxygenase activity
GO:0051747	cytosine C-5 DNA demethylase activity

Biological Process

GO:0006281	DNA repair
GO:0006307	DNA dealkylation involved in DNA repair
GO:0035511	oxidative DNA demethylation
GO:0055114	oxidation-reduction process
GO:0070989	oxidative demethylation
GO:0080111	DNA demethylation