Version 5.4
Homo sapiens Protein: EXOC2
Summary
InnateDB Protein IDBP-55888.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EXOC2
Protein Name exocyst complex component 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000230449
InnateDB Gene IDBG-55886 (EXOC2)
Protein Structure
UniProt Annotation
Function Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Subcellular Localization
Disease Associations
Tissue Specificity Widely expressed with highest levels in brain and placenta. {ECO:0000269PubMed:12459492}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
Experimentally validated
Total 33 [view]
Protein-Protein 33 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0017160 Ral GTPase binding
GO:0047485 protein N-terminus binding
Biological Process
GO:0006887 exocytosis
GO:0006893 Golgi to plasma membrane transport
GO:0015031 protein transport
GO:0044267 cellular protein metabolic process
GO:0061024 membrane organization
Cellular Component
GO:0000145 exocyst
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle
Protein Structure and Domains
PDB ID
InterPro IPR002909 IPT domain
IPR014756 Immunoglobulin E-set
IPR016159 Cullin repeat-like-containing domain
PFAM PF01833
PRINTS
PIRSF
SMART SM00429
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96KP1
PhosphoSite PhosphoSite-Q96KP1
TrEMBL Q2MDF5
UniProt Splice Variant
Entrez Gene 55770
UniGene Hs.484412
RefSeq NP_060773
HUGO HGNC:24968
OMIM 615329
CCDS CCDS34327
HPRD 11544
IMGT
EMBL AJ414403 AK001888 AK314628 AL031770 AL357054 AL512308 AL833213 BC016918 BC080542 CH471087
GenPept AAH16918 AAH80542 BAA91963 BAG37193 CAC92092 CAH70772 CAI19790 CAI46189 EAW55061 EAW55062

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca