InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PPP2R5B

Summary

InnateDB Protein

IDBP-55994.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPP2R5B

Protein Name

protein phosphatase 2, regulatory subunit B', beta

Synonyms

B56B; PR61B;

Species

Homo sapiens

Ensembl Protein

ENSP00000164133

InnateDB Gene

IDBG-55992 (PPP2R5B)

Protein Structure

UniProt Annotation

Function

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The phosphorylated form mediates the interaction between AKT1 and PP2A phosphatase leading to dephosphorylation of AKT1 on the 'Thr-308' and 'Ser-373' residues. {ECO:0000269PubMed:21329884}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:8703017}.

Disease Associations

Tissue Specificity

Highest expression in brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	14 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0008601	protein phosphatase type 2A regulator activity

Biological Process

GO:0006987	activation of signaling protein activity involved in unfolded protein response
GO:0007165	signal transduction
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0044267	cellular protein metabolic process
GO:0050790	regulation of catalytic activity