InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KCNG2

Summary

InnateDB Protein

IDBP-5602.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KCNG2

Protein Name

potassium voltage-gated channel, subfamily G, member 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000315654

InnateDB Gene

IDBG-5600 (KCNG2)

Protein Structure

UniProt Annotation

Function

Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Highly expressed in heart, liver, skeletal muscle, kidney and pancreas. Detected at low levels in brain, lung and placenta.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005251	delayed rectifier potassium channel activity
GO:0005515	protein binding

Biological Process

GO:0006112	energy reserve metabolic process
GO:0006811	ion transport
GO:0006813	potassium ion transport
GO:0007268	synaptic transmission
GO:0008016	regulation of heart contraction
GO:0034765	regulation of ion transmembrane transport
GO:0044281	small molecule metabolic process
GO:0050796	regulation of insulin secretion
GO:0051260	protein homooligomerization
GO:0055085	transmembrane transport
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0008076	voltage-gated potassium channel complex
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000210 BTB/POZ-like
IPR003091 Potassium channel
IPR003131 Potassium channel tetramerisation-type BTB domain
IPR003968 Potassium channel, voltage dependent, Kv
IPR003969 Potassium channel, voltage dependent, Kv6
IPR003971 Potassium channel, voltage dependent, Kv9
IPR005821 Ion transport domain
IPR011333 BTB/POZ fold
IPR013099 Two pore domain potassium channel domain

PFAM

PF02214
PF00520
PF07885

PRINTS

PR00169
PR01491
PR01492
PR01494

PIRSF

SMART

SM00225

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt