Version 5.4
Homo sapiens Protein: MIS18BP1
Summary
InnateDB Protein IDBP-5605.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MIS18BP1
Protein Name MIS18 binding protein 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000309790
InnateDB Gene IDBG-5603 (MIS18BP1)
Protein Structure
UniProt Annotation
Function Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. {ECO:0000269PubMed:17199038, ECO:0000269PubMed:17339379}.
Subcellular Localization Nucleus. Chromosome. Chromosome, centromere. Note=Associated with centromeres in interphase cells, from late anaphase to the G1 phase. Not detected on centromeres during earlier phases of mitosis. Associated with chromatin.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0005515 protein binding
Biological Process
GO:0006334 nucleosome assembly
GO:0007067 mitotic nuclear division
GO:0034080 centromere-specific nucleosome assembly
Cellular Component
GO:0000775 chromosome, centromeric region
GO:0005654 nucleoplasm
Protein Structure and Domains
PDB ID
InterPro IPR001005 SANT/Myb domain
IPR009057 Homeodomain-like
IPR015216 SANT associated
IPR017877 Myb-like domain
PFAM PF00249
PF09133
PRINTS
PIRSF
SMART SM00717
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6P0N0
PhosphoSite PhosphoSite-Q6P0N0
TrEMBL C9J2Q8
UniProt Splice Variant
Entrez Gene 55320
UniGene Hs.732769
RefSeq NP_060823
HUGO HGNC:20190
OMIM
CCDS CCDS9684
HPRD 12629
IMGT
EMBL AB067490 AJ242977 AK002048 AL121809 BC051885 BC065544 CH471078
GenPept AAH51885 AAH65544 BAB67796 CAB45134 EAW65778 EAW65779 EAW65780

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca