InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NAALADL1

Summary

InnateDB Protein

IDBP-56241.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NAALADL1

Protein Name

N-acetylated alpha-linked acidic dipeptidase-like 1

Synonyms

I100; NAALADASEL;

Species

Homo sapiens

Ensembl Protein

ENSP00000351484

InnateDB Gene

IDBG-56237 (NAALADL1)

Protein Structure

UniProt Annotation

Function

NAALADase-like activity unknown. Has no NAAG hydrolyzing activity. Exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC (By similarity). {ECO:0000250}.

Subcellular Localization

Apical cell membrane; Single-pass type II membrane protein. Note=Ileal brush border membrane.

Disease Associations

Tissue Specificity

Mainly expressed in the distal small intestine. Also expressed in the spleen and testis. Weak expression in the brain, locating mainly to the brain stem, amygdala, thalamus and ventral striatum. Isoform 2 and 3 isoform 3 are found in the small intestine and colon.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004180	carboxypeptidase activity
GO:0008233	peptidase activity
GO:0008237	metallopeptidase activity
GO:0016805	dipeptidase activity
GO:0046872	metal ion binding