InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RAB11FIP5

Summary

InnateDB Protein

IDBP-56293.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RAB11FIP5

Protein Name

RAB11 family interacting protein 5 (class I)

Synonyms

GAF1; pp75; RIP11;

Species

Homo sapiens

Ensembl Protein

ENSP00000258098

InnateDB Gene

IDBG-56291 (RAB11FIP5)

Protein Structure

UniProt Annotation

Function

Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis. {ECO:0000269PubMed:11163216, ECO:0000269PubMed:20717956}.

Subcellular Localization

Cytoplasm. Recycling endosome membrane; Peripheral membrane protein. Early endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Mitochondrion membrane; Peripheral membrane protein.

Disease Associations

Tissue Specificity

Detected at low levels in heart, brain, placenta, lung, liver, adipocytes, kidney, spleen, skeletal muscle and pancreas. {ECO:0000269PubMed:10545525, ECO:0000269PubMed:11278501}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	20 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0043015	gamma-tubulin binding

Biological Process

GO:0015031	protein transport
GO:0035773	insulin secretion involved in cellular response to glucose stimulus
GO:0045055	regulated secretory pathway
GO:0071468	cellular response to acidity
GO:2000008	regulation of protein localization to cell surface

Cellular Component

GO:0000139	Golgi membrane
GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005769	early endosome
GO:0005794	Golgi apparatus
GO:0005815	microtubule organizing center
GO:0030141	secretory granule
GO:0030658	transport vesicle membrane
GO:0031901	early endosome membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0055037	recycling endosome
GO:0055038	recycling endosome membrane