InnateDB Protein
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IDBP-56305.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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COL6A5
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Protein Name
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collagen, type VI, alpha 5
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000309762
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InnateDB Gene
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IDBG-56303 (COL6A5)
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Protein Structure
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Function |
Collagen VI acts as a cell-binding protein. {ECO:0000250}.
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Subcellular Localization |
Secreted, extracellular space, extracellular matrix {ECO:0000250}. Note=Deposed in the extracellular matrix of skeletal muscle. {ECO:0000250}.
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Disease Associations |
Note=Patients affected by atopic dermatitis display an abnormal distribution of COL29A1 mRNA and protein in skin suggesting that COL29A1 may be involved in the pathogenesis of the disease.
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Tissue Specificity |
Expressed in skin, followed by lung, small intestine, colon and testis. In skin, it is expressed in the epidermis with strongest staining in suprabasal viable layers. In ATOD patients, it is absent in the most differentiated upper spinous and granular layers (at protein level). {ECO:0000269PubMed:17850181}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002035
von Willebrand factor, type A
IPR008160
Collagen triple helix repeat
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PFAM |
PF00092
PF01391
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PRINTS |
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PIRSF |
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SMART |
SM00327
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TIGRFAMs |
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Modification |
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SwissProt |
A8TX70
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PhosphoSite |
PhosphoSite-A8TX70
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
256076
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UniGene |
Hs.205403
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RefSeq |
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HUGO |
HGNC:26674
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OMIM |
611916
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CCDS |
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HPRD |
08196
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IMGT |
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EMBL |
AC093004
AC117398
AK093199
AK123718
AM906078
AM906079
AM906080
AM906081
AM906082
AM906083
AM906084
EU085556
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GenPept |
ABW81241
BAC04092
BAC85681
CAP19997
CAP19998
CAP19999
CAP20000
CAP20001
CAP20002
CAP20003
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