InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: VPS51

Summary

InnateDB Protein

IDBP-56464.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VPS51

Protein Name

chromosome 11 open reading frame 2

Synonyms

ANG2; ANG3; C11orf2; C11orf3; FFR;

Species

Homo sapiens

Ensembl Protein

ENSP00000279281

InnateDB Gene

IDBG-56462 (VPS51)

Protein Structure

UniProt Annotation

Function

Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi networkl (TGN). The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. VPS51 participates in retrograde transport of acid hydrolase receptors, likely by promoting tethering and SNARE-dependent fusion of endosome-derived carriers to the TGN. {ECO:0000269PubMed:20685960}.

Subcellular Localization

Golgi apparatus, trans-Golgi network {ECO:0000269PubMed:20685960}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.

Experimentally validated
Total	25 [view]
Protein-Protein	24 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding

Biological Process

GO:0006869	lipid transport
GO:0006893	Golgi to plasma membrane transport
GO:0006914	autophagy
GO:0007067	mitotic nuclear division
GO:0015031	protein transport
GO:0042147	retrograde transport, endosome to Golgi

Cellular Component

GO:0000145	exocyst
GO:0000775	chromosome, centromeric region
GO:0000938	GARP complex
GO:0005634	nucleus
GO:0005794	Golgi apparatus
GO:0016021	integral component of membrane
GO:0017119	Golgi transport complex

Protein Structure and Domains

PDB ID

InterPro

IPR007255 Conserved oligomeric Golgi complex subunit 8
IPR009361 RZZ complex, subunit Zw10
IPR016159 Cullin repeat-like-containing domain
IPR019515 Vacuolar protein sorting-associated protein 54
IPR024602 Conserved oligomeric Golgi complex, subunit 2, N-terminal

PFAM

PF04124
PF06248
PF10475
PF06148

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9UID3

PhosphoSite