Version 5.4
Homo sapiens Protein: SNX5
Summary
InnateDB Protein IDBP-56467.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SNX5
Protein Name sorting nexin 5
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000366998
InnateDB Gene IDBG-56465 (SNX5)
Protein Structure
UniProt Annotation
Function May be involved in several stages of intracellular trafficking. Plays a role in macropinocytosis. Plays a role in the internalization of EGFR after EGF stimulation. {ECO:0000269PubMed:18854019, ECO:0000269PubMed:21048941}.
Subcellular Localization Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Cell projection, phagocytic cup. Cell projection, ruffle. Note=Recruited to the plasma membrane after EGF stimulation, which leads to increased levels of phosphatidylinositol 3,4-bisphosphate (PdtIns(3,4)P2). Detected on macropinosomes. Targeted to membrane ruffles in response to EGFR stimulation.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 42 [view]
Protein-Protein 37 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0035091 phosphatidylinositol binding
Biological Process
GO:0006886 intracellular protein transport
GO:0006907 pinocytosis
Cellular Component
GO:0001726 ruffle
GO:0001891 phagocytic cup
GO:0030659 cytoplasmic vesicle membrane
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0031313 extrinsic component of endosome membrane
GO:0031901 early endosome membrane
GO:0070685 macropinocytic cup
Protein Structure and Domains
PDB ID
InterPro IPR001683 Phox homologous domain
IPR014637 Sorting nexin-5/6/32
IPR015404 Vps5 C-terminal
PFAM PF00787
PF09325
PRINTS
PIRSF PIRSF036924
SMART SM00312
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y5X3
PhosphoSite PhosphoSite-Q9Y5X3
TrEMBL
UniProt Splice Variant
Entrez Gene 27131
UniGene Hs.316890
RefSeq NP_689413
HUGO HGNC:14969
OMIM 605937
CCDS CCDS13130
HPRD 10439
IMGT
EMBL AF121855 AK001793 AL121585 BC000100 BC093623 BC093980 BC143274 CH471133
GenPept AAD27828 AAH93623 AAH93980 AAI43275 BAA91914 CAC00471 EAX10264 EAX10265 EAX10266 EAX10268

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca