Version 5.4
Homo sapiens Protein: GLTP
Summary
InnateDB Protein IDBP-56479.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GLTP
Protein Name glycolipid transfer protein
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000315263
InnateDB Gene IDBG-56477 (GLTP)
Protein Structure
UniProt Annotation
Function Accelerates the intermembrane transfer of various glycolipids. Catalyzes the transfer of various glycosphingolipids between membranes but does not catalyze the transfer of phospholipids. May be involved in the intracellular translocation of glucosylceramides. {ECO:0000269PubMed:15329726, ECO:0000269PubMed:15504043, ECO:0000269PubMed:17980653, ECO:0000269PubMed:18261224}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:17980653}.
Disease Associations
Tissue Specificity Detected in fibroblasts (at protein level). Detected in fibroblasts and in various cancer cell lines. {ECO:0000269PubMed:17980653, ECO:0000269PubMed:18261224}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008289 lipid binding
GO:0017089 glycolipid transporter activity
GO:0051861 glycolipid binding
Biological Process
GO:0046836 glycolipid transport
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR014830 Glycolipid transfer protein domain
PFAM PF08718
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NZD2
PhosphoSite PhosphoSite-Q9NZD2
TrEMBL E7CEM8
UniProt Splice Variant
Entrez Gene 51228
UniGene Hs.381256
RefSeq NP_057517
HUGO HGNC:24867
OMIM 608949
CCDS CCDS9136
HPRD 16409
IMGT
EMBL AF209704 AK313457 AY372530 AY372531 AY372532 BC009932 CH471054 GU971358
GenPept AAF33210 AAH09932 AAR85984 AAR85985 AAR87373 ADT71769 BAG36244 EAW97880 EAW97881

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca