InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TM7SF2

Summary

InnateDB Protein

IDBP-56496.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TM7SF2

Protein Name

transmembrane 7 superfamily member 2

Synonyms

ANG1; DHCR14A; NET47;

Species

Homo sapiens

Ensembl Protein

ENSP00000279263

InnateDB Gene

IDBG-56494 (TM7SF2)

Protein Structure

UniProt Annotation

Function

Involved in the conversion of lanosterol to cholesterol. {ECO:0000269PubMed:11784322}.

Subcellular Localization

Microsome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000269PubMed:9878250}; Multi-pass membrane protein {ECO:0000269PubMed:9878250}.

Disease Associations

Tissue Specificity

Expressed in adult heart, brain, pancreas, lung, liver, skeletal muscle, kidney, ovary, prostate, and testis, but not detected in placenta, spleen, thymus, small intestine, colon (mucosal lining), or peripheral blood leukocytes. {ECO:0000269PubMed:9878250}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
GO:0050613	delta14-sterol reductase activity

Biological Process

GO:0006695	cholesterol biosynthetic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0043235	receptor complex