InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BCL3

Summary

InnateDB Protein

IDBP-56570.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BCL3

Protein Name

B-cell CLL/lymphoma 3

Synonyms

BCL4; D19S37;

Species

Homo sapiens

Ensembl Protein

ENSP00000164227

InnateDB Gene

IDBG-56568 (BCL3)

Protein Structure

UniProt Annotation

Function

Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus. Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Note=Ubiquitination via 'Lys- 63'-linked ubiquitin chains is required for nuclear accumulation. {ECO:0000250}.

Disease Associations

Note=A chromosomal aberration involving BCL3 may be a cause of B-cell chronic lymphocytic leukemia (B-CLL). Translocation t(14;19)(q32;q13.1) with immunoglobulin gene regions.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 84 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	84 [view]
Protein-Protein	73 [view]
Protein-DNA	11 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0030674	protein binding, bridging

Biological Process

GO:0000060	protein import into nucleus, translocation
GO:0002268	follicular dendritic cell differentiation
GO:0002315	marginal zone B cell differentiation
GO:0002455	humoral immune response mediated by circulating immunoglobulin
GO:0002467	germinal center formation
GO:0006351	transcription, DNA-templated
GO:0006974	cellular response to DNA damage stimulus
GO:0007249	I-kappaB kinase/NF-kappaB signaling
GO:0009615	response to virus
GO:0010225	response to UV-C
GO:0019730	antimicrobial humoral response
GO:0030198	extracellular matrix organization
GO:0030330	DNA damage response, signal transduction by p53 class mediator
GO:0032729	positive regulation of interferon-gamma production
GO:0042088	T-helper 1 type immune response
GO:0042345	regulation of NF-kappaB import into nucleus
GO:0042536	negative regulation of tumor necrosis factor biosynthetic process
GO:0042742	defense response to bacterium
GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0042832	defense response to protozoan
GO:0042981	regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0045064	T-helper 2 cell differentiation
GO:0045082	positive regulation of interleukin-10 biosynthetic process
GO:0045087	innate immune response (InnateDB)
GO:0045415	negative regulation of interleukin-8 biosynthetic process
GO:0045727	positive regulation of translation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048536	spleen development
GO:0051101	regulation of DNA binding
GO:0051457	maintenance of protein location in nucleus

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0032996	Bcl3-Bcl10 complex
GO:0033257	Bcl3/NF-kappaB2 complex
GO:0043234	protein complex
GO:0045171	intercellular bridge
GO:0048471	perinuclear region of cytoplasm