InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NEK11

Summary

InnateDB Protein

IDBP-56577.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NEK11

Protein Name

NIMA (never in mitosis gene a)- related kinase 11

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000372857

InnateDB Gene

IDBG-56571 (NEK11)

Protein Structure

UniProt Annotation

Function

Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation. {ECO:0000269PubMed:12154088, ECO:0000269PubMed:19734889, ECO:0000269PubMed:20090422}.

Subcellular Localization

Nucleus. Nucleus, nucleolus. Note=Nuclear during interphase but moves to the polar microtubules during prometaphase and metaphase. Accumulates in the nucleolus in G1/S- arrested cells.

Disease Associations

Tissue Specificity

Poorly expressed in cerebellum, trachea, lung, appendix, and uterus. {ECO:0000269PubMed:12154088}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0046872	metal ion binding

Biological Process

GO:0006468	protein phosphorylation
GO:0031572	G2 DNA damage checkpoint
GO:0031573	intra-S DNA damage checkpoint
GO:0035556	intracellular signal transduction

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt