Version 5.4
Homo sapiens Protein: SERPINB1
Summary
InnateDB Protein IDBP-56588.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SERPINB1
Protein Name serpin peptidase inhibitor, clade B (ovalbumin), member 1
Synonyms EI; ELANH2; HEL57; LEI; M/NEI; MNEI; PI-2; PI2;
Species Homo sapiens
Ensembl Protein ENSP00000370115
InnateDB Gene IDBG-56586 (SERPINB1)
Protein Structure
UniProt Annotation
Function Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3. Also functions as a potent intracellular inhibitor of granzyme H. {ECO:0000269PubMed:11747453}.
Subcellular Localization Cytoplasm {ECO:0000250}. Cytoplasmic granule {ECO:0000269PubMed:23269243}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004867 serine-type endopeptidase inhibitor activity
Biological Process
GO:0010951 negative regulation of endopeptidase activity
GO:0030162 regulation of proteolysis
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR023796 Serpin domain
PFAM PF00079
PRINTS
PIRSF
SMART SM00093
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P30740
PhosphoSite PhosphoSite-P30740
TrEMBL V9HWH1
UniProt Splice Variant
Entrez Gene 1992
UniGene
RefSeq NP_109591
HUGO HGNC:3311
OMIM 130135
CCDS CCDS4477
HPRD 00555
IMGT
EMBL AF053630 AK223370 AK291327 AK298044 AK304641 AL139092 BC009015 BT006928 CH471087 EU794624 M93056
GenPept AAC31394 AAH09015 AAP35574 ACJ13678 BAD97090 BAF84016 BAG60342 BAG65420 CAH73667 EAW55089 EAW55090

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca