InnateDB Protein
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IDBP-56605.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TPRKB
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Protein Name
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TP53RK binding protein
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000325398
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InnateDB Gene
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IDBG-56603 (TPRKB)
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Protein Structure
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Function |
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TPRKB acts as an allosteric effector that regulates the t(6)A activity of the complex. TPRKB is not required for tRNA modification (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm. Nucleus.
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Disease Associations |
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Tissue Specificity |
Widely expressed. {ECO:0000269PubMed:12659830}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
42
[view]
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Protein-Protein |
39
[view]
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Protein-DNA |
3
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR013926
CGI121/TPRKB
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PFAM |
PF08617
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9Y3C4
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PhosphoSite |
PhosphoSite-Q9Y3C4
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
51002
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UniGene |
Hs.157401
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RefSeq |
XP_005264400
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HUGO |
HGNC:24259
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OMIM |
608680
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AF060921
AF151879
AY157986
AY157987
BC029492
CH471053
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GenPept |
AAD34116
AAG43133
AAH29492
AAN76356
AAN76357
EAW99720
EAW99722
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